Xfpanel-switch is a nifty little program that aids in managing multiple panel layouts in Xfce. I came across this application when I checked out xubuntu livecd last week. I have now pacakged this application for Fedora. It is available in rawhide and for Fedora releases 24 and 23.
Here are some screenshots -
This is my panel configuration (labeled as nonamedotc) - the one I use on a day to day basis
There are three other configurations available for selection in the default setup.
redmond - "windows" like config
gnome-2 - Old gnome like config
xfce-4.12 - This is Fedora default config
For Fedora 24, you can install the package using
dnf install xfpanel-switch --nogpgcheck